Interleukin-33 Potentiates Bleomycin-Induced Lung Injury
نویسندگان
چکیده
منابع مشابه
Increased basigin in bleomycin-induced lung injury.
Basigin is expressed in many tissues during development, including lung. It is also found on tumor cells and in wounds where it is thought to stimulate adjacent fibroblasts to produce matrix metalloproteinases. To investigate whether basigin might be expressed in fibro-inflammatory lung processes, we generated bleomycin-induced lung injury in mice. At 14 d after intratracheal bleomycin, we foun...
متن کاملIntroduction of the interleukin-10 gene into mice inhibited bleomycin-induced lung injury in vivo.
Interleukin (IL)-10 has been shown to reduce many inflammatory reactions. We investigated the in vivo effects of IL-10 on a bleomycin-induced lung injury model. Hemagglutinating virus of Japan (HVJ)-liposomes containing a human IL-10 expression vector (hIL10-HVJ) or a balanced salt solution as a control (Cont-HVJ) was intraperitoneally injected into mice on day -3. This was followed by intratra...
متن کاملInterleukin-1 receptor-related protein ST2 suppresses the initial stage of bleomycin-induced lung injury.
Acute lung injury has a range of causes, and occasionally leads to lethal respiratory failure. Despite advances in treatment, acute lung injury continues to have a high mortality rate, and thus a new therapeutic approach is needed. ST2 is an interleukin (IL)-1 receptor-related protein, and its expression is induced by various inflammatory responses. Recently, ST2 has been speculated to exert an...
متن کاملInterleukin-33 plays an important role in sepsis-induced acute lung injury in mice
Evidence has shown that Interleukin-33 (IL-33) plays a key role in the early induction and further amplification of sepsis. However, it remains unknown whether IL-33 has effects on sepsis-induced acute lung injury (ALI) and, if so, whether p38MAPK signaling pathway plays any role in it. This study was designed to insight the role of IL-33 in sepsis-induced ALI, and to discover the relationship ...
متن کاملCorilagin Attenuates Aerosol Bleomycin-Induced Experimental Lung Injury
Idiopathic pulmonary fibrosis (IPF) is a progressing lethal disease with few clinically effective therapies. Corilagin is a tannin derivative which shows anti-inflammatory and antifibrotics properties and is potentiated in treating IPF. Here, we investigated the effect of corilagin on lung injury following bleomycin exposure in an animal model of pulmonary fibrosis. Corilagin abrogated bleomyci...
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ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2013
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2013-0093oc